Cell killing

Across TCGA cell cohorts, RNA activity of the Cell killing pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPN1, DOCK10, and LRP6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell killing activity versus GPN1 in CNS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GPN1 →	+0.614	+0.180	.008	.003	3	6
SOFT_TISSUE	DOCK10 →	+3.864	+0.304	.001	<.001	3	5
BLOOD_Leukemia	LRP6 →	-1.797	-0.328	<.001	<.001	3	5
BLOOD_Myeloma	FUZ →	+1.388	+0.227	<.001	.002	3	5
BLOOD_Leukemia	SERPINB8 →	+2.716	+0.285	<.001	.007	3	5
SKIN	POU5F1B →	-0.223	-0.126	<.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001906 vs GPN1 — CNS

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