Retina homeostasis

Across TCGA patient cohorts, RNA activity of the Retina homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIGR_S673, JCHAIN, and MZB1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina homeostasis activity versus PIGR_S673 in HNSC (Pearson r = -0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PIGR_S673 →	+1.349	+0.059	<.001	<.001	3	8
OV	JCHAIN →	+0.896	+0.040	<.001	<.001	3	8
OV	MZB1 →	+1.212	+0.038	.003	<.001	3	8
BRCA	IGHA2 →	+0.567	+0.024	<.001	<.001	3	7
OV	SEC11C →	+0.690	+0.040	.004	<.001	3	6
OV	CD38 →	+0.843	+0.038	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001895 vs PIGR_S673 — HNSC

Explore this scatter interactively →