Retina homeostasis

Across TCGA cell cohorts, RNA activity of the Retina homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A1, MEAK7, and DDX60, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina homeostasis activity versus SLC2A1 in LARGE_INTESTINE (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC2A1 →	+2.094	+0.245	<.001	<.001	3	10
STOMACH	MEAK7 →	+1.441	+0.474	.001	.001	3	6
STOMACH	DDX60 →	+2.221	+0.442	.003	<.001	3	5
LUNG_NSCLC_LUAD	TGFBI →	+3.014	+0.250	.002	.002	3	5
LARGE_INTESTINE	MYB →	-1.704	-0.255	.006	.003	3	5
LARGE_INTESTINE	NIBAN2 →	+0.846	+0.185	.008	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001895 vs SLC2A1 — LARGE_INTESTINE

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