Maternal placenta development

Across TCGA patient cohorts, RNA activity of the Maternal placenta development pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C8A, CLEC3B, and FSTL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maternal placenta development activity versus C8A in COAD (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	C8A →	+0.548	+0.041	<.001	<.001	3	8
GBM	CLEC3B →	+0.538	+0.055	.001	<.001	3	8
BRCA	FSTL1 →	+0.615	+0.056	<.001	<.001	3	8
GBM	MYL6 →	+0.222	+0.039	<.001	<.001	3	8
UCEC	RSU1 →	+0.377	+0.055	.005	.009	3	7
BRCA	TIMP2 →	+0.845	+0.064	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001893 vs C8A — COAD

Explore this scatter interactively →