Maternal placenta development

Across TCGA cell cohorts, RNA activity of the Maternal placenta development pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBBP5, PARP1, and ILF2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Maternal placenta development activity versus RBBP5 in SOFT_TISSUE (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RBBP5 →	+0.708	+0.164	.001	.004	3	8
STOMACH	PARP1 →	+1.003	+0.290	.005	.007	3	7
BLOOD_Leukemia	ILF2 →	+0.722	+0.108	<.001	<.001	3	7
OVARY	PPP1R8 →	+0.486	+0.105	.002	.005	3	6
OVARY	TAF5L →	+0.718	+0.155	<.001	<.001	3	6
OVARY	GEMIN5 →	+0.811	+0.161	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001893 vs RBBP5 — SOFT_TISSUE

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