Embryonic placenta development

Across TCGA patient cohorts, RNA activity of the Embryonic placenta development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C8A, C8B, and ITIH1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic placenta development activity versus C8A in GBM (Pearson r = -0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C8A →	+0.626	+0.031	.001	<.001	3	8
GBM	C8B →	+0.614	+0.028	<.001	.001	3	7
OV	ITIH1 →	+0.672	+0.038	.001	.001	3	7
OV	FSTL1 →	+0.557	+0.030	<.001	<.001	3	7
BRCA	IGFBP3 →	+0.713	+0.029	<.001	<.001	3	7
OV	LAMB1 →	+0.401	+0.034	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001892 vs C8A — GBM

Explore this scatter interactively →