Embryonic placenta development

Across TCGA patient cohorts, RNA activity of the Embryonic placenta development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT18, GGCX, and SEMA3F, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic placenta development activity versus KRT18 in BRCA (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KRT18 →	+1.234	+0.472	<.001	<.001	3	5
BRCA	GGCX →	+0.358	+0.537	.001	<.001	3	4
BRCA	SEMA3F →	+0.979	+0.394	<.001	.003	3	4
BRCA	KRT8 →	+1.097	+0.394	<.001	<.001	3	4
CCRCC	KRT19 →	+2.405	+0.619	<.001	.005	3	4
BRCA	DAG1 →	+0.491	+0.394	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001892 vs KRT18 — BRCA

Explore this scatter interactively →