Embryonic placenta development

Across TCGA cell cohorts, RNA activity of the Embryonic placenta development pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED1, SQOR, and TMEM186, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED1 grouped by Embryonic placenta development-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MED1 →	-0.466	-0.411	<.001	.008	3	6
SOFT_TISSUE	SQOR →	-0.247	-0.802	.001	.004	3	4
OESOPHAGUS	TMEM186 →	-0.319	-0.400	.002	.001	3	4
CNS	MAP2K7 →	+0.255	+0.643	.001	.006	2	5
BREAST	PCDH9 →	+0.161	+0.366	.006	.009	3	4
SKIN	FNTB →	-0.156	-0.370	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED1 by Embryonic placenta development activity — BLOOD_Leukemia

Explore this box plot interactively →