Embryonic placenta development

Across TCGA cell cohorts, RNA activity of the Embryonic placenta development pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN18, PTGFRN, and FCGR2A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSCAN18 grouped by Embryonic placenta development-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZSCAN18 →	-2.537	-1.139	<.001	<.001	3	5
KIDNEY	PTGFRN →	-1.761	-1.354	.005	.005	3	5
KIDNEY	FCGR2A →	+0.934	+1.091	.003	.001	3	5
SOFT_TISSUE	ETV6 →	-0.704	-1.176	.003	.002	3	4
STOMACH	DNAJA2 →	+0.497	+0.263	.001	<.001	3	4
URINARY_TRACT	DDX27 →	+0.923	+2.007	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSCAN18 by Embryonic placenta development activity — KIDNEY

Explore this box plot interactively →