Embryonic placenta development

Across TCGA cell cohorts, RNA activity of the Embryonic placenta development pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF10, TSR1, and NMRK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic placenta development activity versus TNFSF10 in URINARY_TRACT (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TNFSF10 →	+4.686	+0.469	.002	.004	3	6
URINARY_TRACT	TSR1 →	-1.013	-0.464	.005	.001	3	5
URINARY_TRACT	NMRK1 →	+2.095	+0.464	.001	.001	3	4
URINARY_TRACT	MYG1 →	-0.636	-0.464	<.001	.001	3	4
BREAST	UTP4 →	-1.294	-0.965	.002	.007	3	4
URINARY_TRACT	C11orf52 →	+2.860	+0.464	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001892 vs TNFSF10 — URINARY_TRACT

Explore this scatter interactively →