Endothelial cell morphogenesis

Across TCGA patient cohorts, RNA activity of the Endothelial cell morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VTN, C6, and C8A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endothelial cell morphogenesis activity versus VTN in LSCC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VTN →	+0.798	+0.131	<.001	<.001	3	9
GBM	C6 →	+0.926	+0.152	<.001	<.001	3	8
GBM	C8A →	+0.663	+0.101	<.001	.001	3	8
GBM	ITIH2 →	+0.931	+0.149	<.001	<.001	3	8
GBM	SERPIND1 →	+0.598	+0.098	.001	.004	3	7
GBM	CFH →	+0.629	+0.112	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001886 vs VTN — LSCC

Explore this scatter interactively →