Endothelial cell morphogenesis

Across TCGA cell cohorts, RNA activity of the Endothelial cell morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MUSK, PLRG1, and RECQL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MUSK grouped by Endothelial cell morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MUSK →	+0.236	+1.429	.009	.005	3	5
CNS	PLRG1 →	-0.321	-0.189	<.001	<.001	2	5
CNS	RECQL →	+0.128	+0.163	.008	.007	3	4
URINARY_TRACT	KCNA5 →	-0.305	-0.226	.006	.007	3	4
LUNG_NSCLC_LUSC	LNX2 →	-0.271	-0.244	.001	<.001	3	4
BLOOD_Lymphoma	PSMD13 →	+0.187	+2.038	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MUSK by Endothelial cell morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →