Receptor recycling

Across TCGA patient cohorts, RNA activity of the Receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EP300, USP34, and BIRC6, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor recycling activity versus EP300 in DLBC (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	EP300 →	+1.605	+0.052	<.001	<.001	3	33
THYM	USP34 →	+1.713	+0.062	<.001	<.001	3	33
DLBC	BIRC6 →	+1.286	+0.052	<.001	<.001	3	33
THYM	ASH1L →	+1.412	+0.061	<.001	<.001	3	33
UVM	MTR →	+1.307	+0.046	<.001	<.001	3	33
DLBC	UTP25 →	+0.972	+0.047	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001881 vs EP300 — DLBC

Explore this scatter interactively →