Receptor recycling

Across TCGA patient cohorts, RNA activity of the Receptor recycling pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MKI67, NUP35_T273, and RPL7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor recycling activity versus MKI67 in BRCA (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MKI67 →	-0.545	-0.026	<.001	<.001	3	5
OV	NUP35_T273 →	-0.435	-0.028	.004	.002	3	5
BRCA	RPL7 →	-0.277	-0.031	.001	<.001	3	5
BRCA	SRCIN1 →	+0.618	+0.035	<.001	<.001	3	5
GBM	TMA16 →	-0.390	-0.045	<.001	<.001	3	5
BRCA	TKFC →	+0.411	+0.032	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001881 vs MKI67 — BRCA

Explore this scatter interactively →