Receptor recycling

Across TCGA patient cohorts, RNA activity of the Receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYRK1B, PLA1A, and EIF4BP6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor recycling activity versus DYRK1B in GBM (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DYRK1B →	-0.425	-0.241	<.001	<.001	3	4
GBM	PLA1A →	+0.669	+0.191	.002	<.001	3	4
GBM	EIF4BP6 →	-0.615	-0.181	.002	.003	3	4
GBM	HMGB3P9 →	-0.464	-0.157	<.001	.006	3	4
GBM	LRRC37A13P →	-0.275	-0.174	.003	<.001	2	4
HNSC	DHX34 →	-0.436	-0.330	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001881 vs DYRK1B — GBM

Explore this scatter interactively →