Receptor recycling

Across TCGA cell cohorts, RNA activity of the Receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BBIP1, FAM167A, and USP18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BBIP1 grouped by Receptor recycling-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	BBIP1 →	-1.032	-1.169	<.001	.003	3	5
BREAST	FAM167A →	-1.224	-0.924	.004	<.001	3	4
LIVER	USP18 →	+1.696	+1.734	.003	<.001	3	4
STOMACH	SLC4A9 →	-0.091	-1.311	.003	.006	3	4
UPPER_AERODIGESTIVE_TRACT	LRRC42 →	-0.825	-1.280	.002	<.001	3	4
LUNG_NSCLC_LUSC	NPIPB8 →	+0.516	+1.389	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BBIP1 by Receptor recycling activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →