Receptor recycling

Across TCGA cell cohorts, RNA activity of the Receptor recycling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCK2, METAP2, and GCFC2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor recycling activity versus UCK2 in LUNG_NSCLC_LUSC (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UCK2 →	-1.433	-0.478	.001	<.001	3	8
LIVER	METAP2 →	-0.973	-0.482	<.001	<.001	3	7
PANCREAS	GCFC2 →	-0.897	-0.312	<.001	<.001	3	7
OESOPHAGUS	EEF1B2 →	-1.075	-0.343	.002	<.001	3	6
LIVER	PMEPA1 →	+5.344	+0.440	<.001	<.001	3	6
LIVER	RCOR2 →	-2.244	-0.534	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001881 vs UCK2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →