Response to yeast

Across TCGA patient cohorts, RNA activity of the Response to yeast pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLCG2, CRLF3, and CORO1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to yeast activity versus PLCG2 in GBM (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLCG2 →	+0.607	+0.175	<.001	<.001	3	8
UCEC	CRLF3 →	+0.355	+0.084	<.001	<.001	3	7
GBM	CORO1A →	+0.504	+0.144	<.001	<.001	3	7
GBM	ARHGAP45 →	+0.609	+0.167	<.001	<.001	3	7
GBM	BLNK_S129 →	+0.459	+0.110	.003	<.001	3	7
GBM	SKAP2 →	+0.680	+0.153	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001878 vs PLCG2 — GBM

Explore this scatter interactively →