Response to yeast

Across TCGA cell cohorts, RNA activity of the Response to yeast pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGFBP3, SLAIN1, and NR2F6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IGFBP3 grouped by Response to yeast-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IGFBP3 →	+3.495	+1.011	.002	.006	3	4
STOMACH	SLAIN1 →	-1.925	-1.146	.007	.005	3	4
STOMACH	NR2F6 →	+0.904	+1.363	.008	<.001	3	4
BONE	S100A1 →	-0.740	-1.716	.009	<.001	3	4
PANCREAS	ZNF827 →	+1.190	+1.443	<.001	<.001	3	4
KIDNEY	TMEM255B →	+1.711	+1.346	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IGFBP3 by Response to yeast activity — BREAST

Explore this box plot interactively →