"Complement activation, lectin pathway"

Across TCGA patient cohorts, RNA activity of the "Complement activation, lectin pathway" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SAMD9L, GBP1, and RHOG, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Complement activation, lectin pathway" activity versus SAMD9L in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SAMD9L →	+0.508	+0.142	<.001	<.001	3	7
GBM	GBP1 →	+0.773	+0.168	<.001	<.001	3	7
GBM	RHOG →	+0.361	+0.149	.002	<.001	3	6
BRCA	STAT2 →	+0.349	+0.094	<.001	<.001	3	6
LSCC	STK17B →	+0.409	+0.097	<.001	<.001	3	6
LSCC	THEMIS2 →	+0.440	+0.122	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001867 vs SAMD9L — HNSC

Explore this scatter interactively →