"Complement activation, lectin pathway"

Across TCGA cell cohorts, RNA activity of the "Complement activation, lectin pathway" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CABYR, CLTRN, and EFCAB13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CABYR grouped by "Complement activation, lectin pathway"-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CABYR →	-3.282	-0.375	.005	.004	3	3
BLOOD_Lymphoma	CLTRN →	+0.444	+0.336	.001	<.001	3	3
BLOOD_Lymphoma	EFCAB13 →	+1.597	+0.339	.001	.002	3	3
BLOOD_Lymphoma	LRRD1 →	+0.104	+0.329	.003	.006	3	3
URINARY_TRACT	KLF7 →	+1.525	+0.320	<.001	.009	3	3
URINARY_TRACT	RTF1 →	+0.809	+0.371	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CABYR by "Complement activation, lectin pathway" activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →