"Complement activation, lectin pathway"

Across TCGA cell cohorts, RNA activity of the "Complement activation, lectin pathway" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C3, CFB, and TNFSF14, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Complement activation, lectin pathway" activity versus C3 in LIVER (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	C3 →	+5.725	+2.228	<.001	<.001	3	17
LIVER	CFB →	+3.603	+1.667	.001	.006	3	14
BLOOD_Leukemia	TNFSF14 →	+1.799	+0.912	<.001	<.001	3	12
PANCREAS	NEURL3 →	+1.314	+1.390	.003	<.001	3	12
BREAST	TIMELESS →	-1.109	-1.289	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	SAA1 →	+6.639	+1.231	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001867 vs C3 — LIVER

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