"Complement activation, lectin pathway"

Across TCGA cell cohorts, RNA activity of the "Complement activation, lectin pathway" pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYBG2, LRWD1, and TTPAL, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Complement activation, lectin pathway" activity versus CRYBG2 in LUNG_SCLC (Pearson r = -0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CRYBG2 →	-2.756	-1.524	<.001	<.001	3	2
BLOOD_Lymphoma	LRWD1 →	+1.242	+0.192	<.001	.007	3	1
BLOOD_Myeloma	TTPAL →	-1.394	-0.201	.002	.001	3	1
BLOOD_Myeloma	LENG8 →	+1.513	+0.230	<.001	.004	3	1
BLOOD_Myeloma	SYNGAP1 →	+1.546	+0.230	<.001	.004	3	1
LUNG_SCLC	EIF3E →	+1.926	+1.567	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001867 vs CRYBG2 — LUNG_SCLC

Explore this scatter interactively →