NK T cell proliferation

pathway activity — cross-omics
GO:0001866Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the NK T cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX20, RASAL3, and PIK3CG, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECSNX20 →+0.794+1.093<.001<.00139
OVRASAL3 →+0.795+0.776<.001.00938
UCECPIK3CG →+0.882+1.170<.001<.00138
UCECBTK →+0.859+1.015<.001<.00138
HNSCDOCK8 →+0.817+0.867<.001<.00138
UCECLAX1 →+1.217+1.101<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration