NK T cell differentiation

Across TCGA patient cohorts, RNA activity of the NK T cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBP1, LIMD2, and BZW2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NK T cell differentiation activity versus GBP1 in HNSC (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GBP1 →	-0.657	-0.077	<.001	<.001	3	5
HNSC	LIMD2 →	-0.498	-0.087	<.001	<.001	3	5
LSCC	BZW2 →	-0.290	-0.063	.001	.003	3	5
HNSC	TAP1 →	-0.533	-0.081	<.001	<.001	3	4
COAD	UBE2L6 →	-0.407	-0.037	.001	.006	3	4
COAD	CD8A →	-0.957	-0.073	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001865 vs GBP1 — HNSC

Explore this scatter interactively →