NK T cell differentiation

Across TCGA patient cohorts, RNA activity of the NK T cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGMS2, MIR124-1HG, and BDKRB2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NK T cell differentiation activity versus SGMS2 in HNSC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SGMS2 →	+0.511	+0.484	.009	.005	3	3
GBM	MIR124-1HG →	-1.030	-0.518	.008	.002	3	3
PDAC	BDKRB2 →	+0.406	+0.707	.004	.003	3	3
UCEC	PARN →	+0.278	+0.817	.003	<.001	3	3
UCEC	ATG3 →	+0.429	+0.762	.001	<.001	3	3
CCRCC	EIF4E1B →	-0.011	-0.569	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001865 vs SGMS2 — HNSC

Explore this scatter interactively →