Phagolysosome assembly

Across TCGA patient cohorts, RNA activity of the Phagolysosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARF2, SUGCT, and EDIL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagolysosome assembly activity versus SCARF2 in PDAC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SCARF2 →	+0.536	+0.256	<.001	.004	3	5
HNSC	SUGCT →	+0.862	+0.540	.001	.001	3	4
BRCA	EDIL3 →	+1.139	+0.116	.001	<.001	3	4
COAD	RECK →	+0.316	+0.288	.006	.001	3	3
COAD	ISLR →	+0.798	+0.217	.007	.009	3	3
COAD	PALLD →	+0.453	+0.284	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001845 vs SCARF2 — PDAC

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