Phagolysosome assembly

Across TCGA cell cohorts, RNA activity of the Phagolysosome assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM2, INTS12, and ERI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM2 grouped by Phagolysosome assembly-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MDM2 →	+0.637	+0.075	<.001	<.001	3	5
SKIN	INTS12 →	+0.187	+0.068	<.001	.009	3	5
KIDNEY	ERI1 →	+0.207	+0.066	.001	.004	3	5
OVARY	CDK4 →	+0.290	+0.064	.005	<.001	3	5
SOFT_TISSUE	TP53 →	-0.648	-0.089	<.001	<.001	3	4
KIDNEY	ATP1A1 →	-0.471	-0.072	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM2 by Phagolysosome assembly activity — SKIN

Explore this box plot interactively →