Neural plate development

pathway activity — cross-omics
GO:0001840Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Neural plate development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STRBP, PPP1R18_S368, and TSN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCASTRBP →+0.414+0.063<.001<.00136
COADPPP1R18_S368 →-0.466-0.045.002.00135
LSCCTSN →+0.286+0.056.001.00235
BRCASMARCC2 →+0.271+0.076<.001<.00135
BRCAFSCN1 →-0.535-0.058<.001<.00135
HNSCSSB →+0.333+0.097<.001.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration