Neural plate morphogenesis

pathway activity — cross-omics
GO:0001839Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Neural plate morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNPC3_S108, TPX2, and CSE1L, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
PDACRNPC3_S108 →+0.244+0.039.003.00337
PDACTPX2 →+0.502+0.055<.001.00436
GBMCSE1L →+0.299+0.089<.001.00136
LUADHMGB3 →+0.857+0.071<.001.00136
LUADXRCC1_S241 →+0.895+0.101.003.00136
PDACADAMTSL2 →-0.487-0.035.001.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration