Epithelial to mesenchymal transition

Across TCGA patient cohorts, RNA activity of the Epithelial to mesenchymal transition pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NIPSNAP3B, TLDC2, and CEACAM8, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial to mesenchymal transition activity versus NIPSNAP3B in COAD (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NIPSNAP3B →	+0.582	+0.895	<.001	.002	3	2
BRCA	TLDC2 →	+0.330	+0.194	.004	.009	3	1
BRCA	CEACAM8 →	+0.070	+0.291	<.001	.009	3	1
BRCA	NR2F1 →	+4.731	+0.194	.003	.009	3	1
BRCA	PROS2P →	+0.080	+0.291	.002	.009	3	1
BRCA	RNU1-100P →	+0.720	+0.291	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001837 vs NIPSNAP3B — COAD

Explore this scatter interactively →