Release of cytochrome c from mitochondria

Across TCGA patient cohorts, RNA activity of the Release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, LMNA, and HCFC1R1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Release of cytochrome c from mitochondria activity versus ACTA2 in BRCA (Pearson r = 0.06).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACTA2 →	+0.922	+0.189	.006	.002	3	6
LSCC	LMNA →	+0.547	+0.159	.003	<.001	3	6
BRCA	HCFC1R1 →	+0.736	+0.213	.001	<.001	3	5
BRCA	SFXN3 →	+0.584	+0.259	.003	<.001	3	5
GBM	TMPO →	-0.346	-0.134	.008	.001	3	5
LUAD	AOC3 →	+0.550	+0.169	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001836 vs ACTA2 — BRCA

Explore this scatter interactively →