Release of cytochrome c from mitochondria

Across TCGA cell cohorts, RNA activity of the Release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADGRF4, IPO13, and MAP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADGRF4 grouped by Release of cytochrome c from mitochondria-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ADGRF4 →	+1.544	+1.304	.002	.001	3	4
PANCREAS	IPO13 →	-0.832	-0.989	.001	.004	3	4
PANCREAS	MAP4 →	-0.673	-0.742	<.001	<.001	3	4
LUNG_NSCLC_LUAD	WDR48 →	-0.573	-0.917	.002	<.001	3	4
OVARY	LRFN4 →	-0.827	-0.625	.009	.008	3	3
CNS	SNX21 →	-1.118	-0.997	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADGRF4 by Release of cytochrome c from mitochondria activity — KIDNEY

Explore this box plot interactively →