Release of cytochrome c from mitochondria

Across TCGA cell cohorts, RNA activity of the Release of cytochrome c from mitochondria pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAX, MLXIPL, and PSMB5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAX grouped by Release of cytochrome c from mitochondria-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAX →	-0.647	-0.136	<.001	.001	3	7
LUNG_NSCLC_LUSC	MLXIPL →	-0.198	-0.124	.006	.006	3	5
SKIN	PSMB5 →	-0.448	-0.152	<.001	.001	3	5
BREAST	TMED2 →	+0.271	+0.069	.001	.009	2	5
LUNG_NSCLC_LUSC	ZBTB17 →	+0.175	+0.112	.001	.002	3	4
BONE	PPP1R12A →	+0.567	+0.187	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAX by Release of cytochrome c from mitochondria activity — BONE

Explore this box plot interactively →