Release of cytochrome c from mitochondria

Across TCGA cell cohorts, RNA activity of the Release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD3, IRF1, and GBP3, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Release of cytochrome c from mitochondria activity versus SMAD3 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SMAD3 →	+1.734	+0.138	<.001	.001	3	15
BONE	IRF1 →	+1.752	+0.121	<.001	<.001	3	13
BONE	GBP3 →	+3.375	+0.110	<.001	<.001	3	12
BREAST	PARP12 →	+1.161	+0.088	<.001	<.001	3	12
LUNG_NSCLC_LUSC	SAMD9 →	+3.211	+0.181	<.001	<.001	3	12
BONE	TTC7A →	+1.683	+0.148	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001836 vs SMAD3 — UPPER_AERODIGESTIVE_TRACT

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