Release of cytochrome c from mitochondria

Across TCGA cell cohorts, RNA activity of the Release of cytochrome c from mitochondria pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VRK3, GET1, and ZNF175, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Release of cytochrome c from mitochondria activity versus VRK3 in OESOPHAGUS (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	VRK3 →	+0.961	+0.308	.005	.002	3	4
OESOPHAGUS	GET1 →	+0.864	+0.239	.005	.003	3	4
KIDNEY	ZNF175 →	+1.289	+0.229	.001	.007	3	4
BLOOD_Leukemia	ST3GAL4 →	+1.555	+0.159	.004	.009	3	4
BREAST	F11R →	+1.318	+0.183	.005	.002	3	4
BLOOD_Leukemia	CCDC107 →	-0.507	-0.121	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001836 vs VRK3 — OESOPHAGUS

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