Blastocyst growth

Across TCGA pan-cancer cohorts, RNA activity of the Blastocyst growth pathway differs between tumor and matched normal tissue in 13 of the 18 cancer types tested.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

BLCA, LUAD, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BLCA	Male	All	+0.096	<.001	12	view →
LUAD	Male	III,IV	+0.088	<.001	9	view →
KIRP	All	II,III,IV	+0.063	<.001	9	view →
HNSC	Male	IV	+0.057	<.001	9	view →
COAD	All	III,IV	+0.045	<.001	9	view →
LUSC	All	III,IV	+0.140	<.001	8	view →
UCEC	All	III,IV	+0.101	<.001	6	view →
STAD	All	II,III,IV	+0.078	<.001	6	view →
KIRC	Male	All	+0.017	.002	6	view →
LIHC	Male	All	+0.031	<.001	4	view →
BRCA	All	II,III,IV	+0.024	<.001	4	view →
CHOL	Male	All	+0.096	<.001	3	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 13 lineages.

GO:0001832–BLCA

Open the BLCA breakdown →