Trophectodermal cell differentiation

Across TCGA patient cohorts, RNA activity of the Trophectodermal cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADA, IKBIP, and SERPINH1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trophectodermal cell differentiation activity versus ADA in CCRCC (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ADA →	+0.449	+0.041	<.001	.004	3	6
OV	IKBIP →	+0.442	+0.055	<.001	<.001	3	6
OV	SERPINH1 →	+0.505	+0.055	.001	<.001	3	5
OV	C1R →	+0.560	+0.042	<.001	<.001	3	5
OV	HIRIP3 →	-0.518	-0.062	<.001	<.001	3	5
CCRCC	DDAH1 →	-0.562	-0.057	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001829 vs ADA — CCRCC

Explore this scatter interactively →