Trophectodermal cell differentiation

Across TCGA patient cohorts, RNA activity of the Trophectodermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIER2, INPP5E, and DOT1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trophectodermal cell differentiation activity versus MIER2 in OV (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MIER2 →	+0.538	+0.558	.002	.003	3	4
OV	INPP5E →	+0.854	+0.659	<.001	.002	3	4
OV	DOT1L →	+1.012	+0.527	<.001	.007	3	3
OV	SF3A2 →	+0.998	+0.575	.006	.002	3	3
OV	DPH7 →	+0.553	+0.502	<.001	.009	3	3
OV	SELENON →	+0.875	+0.782	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001829 vs MIER2 — OV

Explore this scatter interactively →