Trophectodermal cell differentiation

Across TCGA cell cohorts, RNA activity of the Trophectodermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HNRNPA1, UBFD1, and RBBP4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trophectodermal cell differentiation activity versus HNRNPA1 in BLOOD_Leukemia (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HNRNPA1 →	+0.386	+0.392	.001	.002	3	7
PANCREAS	UBFD1 →	+1.008	+1.332	.008	.002	3	6
BLOOD_Leukemia	RBBP4 →	+0.614	+0.346	.002	.007	3	6
PANCREAS	SPATS2 →	+1.185	+1.124	.001	.006	3	5
OESOPHAGUS	RPA2 →	+0.646	+1.267	.007	<.001	2	6
BLOOD_Leukemia	ATXN7L3B →	+0.810	+0.708	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001829 vs HNRNPA1 — BLOOD_Leukemia

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