Trophectodermal cell differentiation

Across TCGA cell cohorts, RNA activity of the Trophectodermal cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNOT2, NACA, and PTGES3, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trophectodermal cell differentiation activity versus CNOT2 in LIVER (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CNOT2 →	+1.685	+1.823	.003	<.001	2	20
STOMACH	NACA →	+2.589	+1.450	.001	.006	3	18
STOMACH	PTGES3 →	+2.580	+1.703	.001	<.001	3	18
LARGE_INTESTINE	CCT6B →	+1.981	+1.452	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	RPS20 →	+1.633	+1.442	<.001	<.001	3	17
STOMACH	RPS14 →	+1.238	+1.670	.003	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001829 vs CNOT2 — LIVER

Explore this scatter interactively →