Inner cell mass cell differentiation

Across TCGA patient cohorts, RNA activity of the Inner cell mass cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, STXBP2, and CARD9_S460, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inner cell mass cell differentiation activity versus KANK2 in CCRCC (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KANK2 →	+0.387	+0.063	<.001	<.001	3	7
LSCC	STXBP2 →	-0.236	-0.087	<.001	.001	3	6
LSCC	CARD9_S460 →	-0.396	-0.062	<.001	<.001	3	6
LSCC	CBX1 →	+0.316	+0.074	<.001	<.001	3	6
CCRCC	DIAPH1 →	-0.271	-0.064	.001	<.001	3	6
LUAD	FAM98B →	+0.142	+0.047	.007	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001826 vs KANK2 — CCRCC

Explore this scatter interactively →