Inner cell mass cell differentiation

Across TCGA cell cohorts, RNA activity of the Inner cell mass cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GAPDH, ASGR2, and DEK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GAPDH grouped by Inner cell mass cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GAPDH →	-0.412	-0.943	.001	<.001	3	5
LUNG_NSCLC_LUSC	ASGR2 →	+0.323	+1.787	.001	<.001	3	4
LIVER	DEK →	+0.233	+1.373	.003	.006	3	4
LUNG_NSCLC_LUSC	INPPL1 →	+0.373	+1.470	<.001	.001	3	3
STOMACH	REXO1 →	+0.197	+1.321	.001	.003	3	3
SOFT_TISSUE	CEACAM4 →	-0.307	-1.046	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GAPDH by Inner cell mass cell differentiation activity — BREAST

Explore this box plot interactively →