Blastocyst formation

Across TCGA patient cohorts, RNA activity of the Blastocyst formation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NSD2, TICRR, and FANCG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blastocyst formation activity versus NSD2 in BRCA (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NSD2 →	+0.447	+0.138	<.001	.008	3	5
BRCA	TICRR →	+0.754	+0.199	<.001	.003	3	5
BRCA	FANCG →	+0.430	+0.253	<.001	<.001	3	4
BRCA	RNA5SP351 →	-0.287	-0.185	<.001	.003	3	4
GBM	NEDD1 →	+0.317	+0.174	.002	.001	3	4
GBM	SPAG5-AS1 →	+0.318	+0.185	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001825 vs NSD2 — BRCA

Explore this scatter interactively →