Blastocyst formation

Across TCGA cell cohorts, RNA activity of the Blastocyst formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5MD, ZNF468, and PRSS51, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP5MD grouped by Blastocyst formation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ATP5MD →	-1.013	-0.362	.004	<.001	3	4
LARGE_INTESTINE	ZNF468 →	+1.071	+0.200	.006	.003	3	3
LARGE_INTESTINE	PRSS51 →	+1.196	+0.279	.009	.001	3	3
BLOOD_Leukemia	AKAP3 →	+0.635	+0.548	.001	.003	3	3
BLOOD_Leukemia	DPF2 →	+0.441	+0.572	.005	.002	3	3
BLOOD_Leukemia	AGTRAP →	-1.972	-0.540	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP5MD by Blastocyst formation activity — BLOOD_Myeloma

Explore this box plot interactively →