Blastocyst development

Across TCGA patient cohorts, RNA activity of the Blastocyst development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNA2, SPC25, and CENPH, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blastocyst development activity versus DNA2 in GBM (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DNA2 →	+0.738	+0.268	<.001	<.001	3	8
GBM	SPC25 →	+1.106	+0.236	<.001	.001	3	8
GBM	CENPH →	+0.920	+0.258	<.001	<.001	3	7
GBM	PRIM2 →	+0.578	+0.306	<.001	<.001	3	7
LUAD	DSN1 →	+0.758	+0.209	<.001	<.001	3	7
GBM	EME1 →	+0.754	+0.222	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001824 vs DNA2 — GBM

Explore this scatter interactively →