Blastocyst development

Across TCGA cell cohorts, RNA activity of the Blastocyst development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIP13, ETV6, and SLC9A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIP13 grouped by Blastocyst development-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TRIP13 →	-0.940	-0.345	.009	.002	3	4
CNS	ETV6 →	-0.765	-0.879	.003	.004	3	4
LUNG_SCLC	SLC9A3 →	-1.923	-0.420	.003	.002	3	4
KIDNEY	GMIP →	-0.706	-1.126	.008	.003	3	4
PANCREAS	KTI12 →	-0.605	-1.151	.004	.001	3	4
OVARY	MIER1 →	-0.664	-1.060	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIP13 by Blastocyst development activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →