Blastocyst development

Across TCGA cell cohorts, RNA activity of the Blastocyst development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL10, EIF3I, and TMEM177, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Blastocyst development activity versus MRPL10 in LUNG_NSCLC_LUAD (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MRPL10 →	+0.443	+0.661	.003	.003	3	6
BLOOD_Leukemia	EIF3I →	+0.417	+0.237	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	TMEM177 →	+0.885	+1.096	<.001	<.001	3	6
BLOOD_Leukemia	KHDRBS1 →	+0.646	+0.292	<.001	<.001	3	6
BLOOD_Leukemia	KMT2A →	+1.120	+0.344	<.001	<.001	3	6
PANCREAS	RBBP4 →	+0.922	+1.082	.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001824 vs MRPL10 — LUNG_NSCLC_LUAD

Explore this scatter interactively →