Mesonephros development

Across TCGA patient cohorts, RNA activity of the Mesonephros development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UACA, PRKD1, and CLEC14A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesonephros development activity versus UACA in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UACA →	+0.443	+0.196	<.001	.002	3	6
HNSC	PRKD1 →	+0.828	+0.766	<.001	<.001	3	6
COAD	CLEC14A →	+0.650	+0.481	.002	<.001	3	6
BRCA	ZNF471 →	+0.704	+0.252	.004	.009	3	6
CCRCC	AMOTL1 →	+0.661	+0.637	<.001	.003	3	6
CCRCC	RNF152 →	+1.105	+0.583	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0001823 vs UACA — BRCA

Explore this scatter interactively →