Mesonephros development

Across TCGA cell cohorts, RNA activity of the Mesonephros development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST3GAL6, IQCC, and ACOT4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST3GAL6 grouped by Mesonephros development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ST3GAL6 →	-1.430	-0.697	.003	.003	3	4
LUNG_NSCLC_LUAD	IQCC →	-0.458	-0.443	.007	.007	2	4
BREAST	ACOT4 →	+1.532	+0.829	.002	.001	3	3
OVARY	SYT12 →	-0.994	-0.705	.009	<.001	3	2
OVARY	PNPLA2 →	-0.738	-0.728	<.001	<.001	3	2
LUNG_NSCLC_LUAD	CKMT2 →	+0.217	+0.467	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST3GAL6 by Mesonephros development activity — BREAST

Explore this box plot interactively →